MATH+ Protocol Includes Ivermectin Option for Prophylaxis and Early Treatment of COVID-19; Phase of Disease Key to Care

Oct 14, 2020 | COVID-19, Ivermectin, MATH+, News, Popular Posts, Prophylaxis

MATH+ Protocol Includes Ivermectin Option for Prophylaxis and Early Treatment of COVID-19; Phase of Disease Key to Care

“MATH+” is the COVID-19 protocol by Dr. Paul Marik and the (FLCCC), as previously reported by TrialSite. And while NIH is still ivermectin be used only in clinical trials, the September 28 to MATH+ includes this drug as described below. The protocol notes that it, “is our recommended approach to COVID-19 based on the best (and most recent) literature. This is a very dynamic situation; therefore, we will be updating the guideline as new information emerges.” Beginning with prophylaxis, or prevention, the protocol notes that a safe and effective “cocktail” of substances may prevent or mitigate COVID-19. For this purpose, Marik recommends melatonin, high-dose vitamin D3 (deficiency of which has been tied to increased risk of catching COVID-19 and worse outcomes), vitamin C, zinc, and famotidine. For post-exposure prophylaxis, home-treatment during the acute phase, and mildly symptomatic hospital patients, ivermectin is listed as an optional medication.

The Phase Dictates the Approach

The MATH+ protocol emphasizes that COVID-19 has different phases requiring different approaches. For example, antivirals likely only help during the initial viral replication phase, and anti-inflammatories are, “expected to be effective during the pulmonary phase and possibly the post-COVID-19 phase.” And as patients progress, “down the pulmonary cascade,” the disease is much more difficult to reverse. Early treatment in the pulmonary phase is, to quote, “ESSENTIAL” to a positive outcome. In this phase, MATH+ indicates anti-inflammatories for cytokine storms plus anticoagulants to limit vascular clotting. If the “storm” is not stopped, often patients do not recover. The scientific basis for the MATH+ protocol is reviewed in an in the Expert Review of Anti-Infective Therapy. And an interesting talk from Dr. Marik on COVID-19 is found .

Who Is Dr. Marik?

, MD, FCCP, FCCM, is Chief of Pulmonary and Critical Care Medicine at in Norfolk, Virginia. Dr. Marik got his MD at the Witwatersrand, in Johannesburg, South Africa. He also has a Master of Medicine degree, a Bachelor of Science in Pharmacology, and diplomas in Anesthesia and Tropical Medicine and Hygiene. Dr. Marik is a Fellow to the Royal College of Physicians and Surgeon of Canada, and he is board certified in Internal Medicine, Critical Care Medicine, and Nutrition Science. Dr. Marik’s work includes over 400 peer-reviewed articles, 50 book chapters, and four books on critical care. 



  1. ML

    Dr. Paul Marik, is one of my heroes in this Covid-19 crisis. I’ve watched him speak several times and he is truly a blessing to humanity in these pandemic times. I await his monthly MATH+ protocol updates with great happiness. Eastern Virginia Medical School is LUCKY to have him.

  2. Mary

    I think this is what the President was taking. See Conley’s notes. @ pbleic remarks. Big repurposed drug fan but better rethink this.

  3. Hoyt Nelson

    Dr. Marik’s protocol has included ivermectin 150-200mg as optional treatment of infected patients at home or mildly-ill hospitalized patients, going all the way back to May 28 (my oldest version of his protocol).

    The difference between the most recent version (2020-09-28) and the next-most-recent version I have (2020-08-01) is the ADDITION of ivermectin for PROPHYLAXIS — for uninfected people trying to avoid catching COVID-19.

    > Optonal: Ivermectn for postexposure prophylaxis (see NCT04422561)

    That trial is the Egyptian study that gave newly-covid+ patients enough ivermectin so the new patient’s household members could take two doses. Only 7.4% of household members who took ivermectin caught the virus, compared to 58.4% of those in the without-ivermectin households, during the ensuing 3 weeks. I wrote it up here:

    Between 2020-08-01 and 2020-09-28, Dr. Marik also added to his recommended prophylaxis regimen:

    • Famotdine 20-40 mg/day

    • Optonal/Experimental: Interferon-α nasal spray for health care workers

    This is the paper Dr. Marik cites as the basis for the nasal spray recommendation:

    I posted the link in case someone wants to read it, and googles the title, which oddly doesn’t work; google returns a couple unrelated papers. I found it using bing. I’m not shilling for bing, honest!

    💖 Ivermectin for prophylaxis! 😍

    Who needs a 50-70% effective vaccine? 🤷‍♀️🤷‍♂️

    (Not that I’ll turn down the vaccine, when it finally arrives.)


Submit a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. .

Pin It on Pinterest